Many adults born with OA/TOF have been on PPI for many years, and some since their inception in the 1980s. These adults may approach the GP to discuss concerns about side-effects of long-term use of PPIs, which, whilst certainly present, need weighing against the risks of possible lifelong untreated acid reflux disease.
Intermittent monitoring of iron, magnesium, B12, Vitamin D is recommended for those on long-term PPIs as those with OA/TOF may have other causes of malabsorption. Assessment of osteoporosis risk is also recommended. (92)